Fastest way to drive to  Big Bend from Houston is take I-10 about 200 mi. to San Antonio, and either continue I-10 about 315 mi. to Fort Stockton, or you can take US 90 from San Antonio about 160 mi. to  Del Rio, then 175 mi. to Marathon.

Directions from San Antonio

By taking different routes to and from Big Bend, you can see lots of Texas.